Traditional rivals Kaizer Chiefs and Orlando Pirates are substantially off the pace, not coping well under pressure and in varying states of flux.
Mamelodi Sundowns dominated the game to take the Telkom Knockout Final trophy, in a 3-1 win.
Dutchman Alje Schut is to play his last game in South Africa.
Mamelodi Sundowns have imploded, opening the door for two other clubs to bump them out of second place.
After tepid home displays South Africa's three representatives are likely to bow out of Africa.
Chiefs will have to be creative and Downs will be well-prepared for their next round in the Champions League.
The Mamelodi Sundowns coach is confident his club can bypass Chiefs for the PSL title, as they did last season.
Coach Pitso Mosimane, with a large pool of players, has embraced the continental mission.
For the Premier Soccer League's top contenders form is key and they'll rely on their star players.
PSL heavyweights Mamelodi Sundowns and SuperSport United go on an all-out spending spree to acquire new full-strength lines-ups.
The victory pushes Sundowns to 23 points on the table, while for Stars it was their eighth loss that left them with only 14 points.
Gordon Igesund says it will be difficult to catch Kaizer Chiefs, especially after SuperSport United's 3-1 loss to Mamelodi Sundowns on Wednesday.
Inconsistent Sundowns will have to pull out all the stops to dent Amakhosi's 11-point league lead.
Mamelodi Sundowns have come back from a mauling by Orlando Pirates to beat AmaZulu 2-0 in their bid to defend their title.
If Patrice Motsepe's chequebook alone can guarantee victory for the Brazilians, then the rest might as well pack up and go home.
Mosimane has finally led Sundowns to a PSL title – now he is in the market for new players to drive his 'adventures' on the continent.
Mamelodi Sundowns credit teamwork for finally winning the Premier Soccer League again after a SuperSport United victory.
Sundowns are excited to be close to winning the title. But even if they win on Tuesday, the trophy will only be handed out at the end of the season.
Mamelodi Sundowns coach Pitso Mosimane has acknowledged owing a bottle of very decent wine to Bidvest Wits coach Gavin Hunt.