Egypt's Zamalek come to town to face a Pirates side that has excelled in recent African matches.
Orlando Pirates conceded two goals before hitting back to force a 2-2 draw against Gabonese Mounana Sunday in a CAF Confederation Cup last-16 clash.
After tepid home displays South Africa's three representatives are likely to bow out of Africa.
With Kaizer Chiefs back to winning ways in the league and Pirates floundering in their wake, this weekend's Soweto derby has lost its edge.
Algeria has named a final squad for the 2015 Africa Cup of Nations in Equatorial Guinea while Group C rivals Ghana and South Africa are undecided.
Not for decades have the Soweto giants headed into the derby with such contrasting fortunes – Chiefs look unstoppable while Pirates are crumbling.
Orlando Pirates coach Vladimir Vermezovic wants his team to go on and focus on the upcoming game against Kaizer Chiefs after their defeat to United.
The Orlando Pirates beat SuperSport United 2-1, climbing to fourth place in the Premiership standings.
Orlando Pirates take to the field for the first time since Senzo Meyiwa's death and their reaction will decide the outcome of the game.
The 27-year-old Bafana Bafana and Orlando Pirates captain and goalkeeper, Senzo Meyiwa, was shot and killed during a botched robbery on Sunday, 26 October 2014.
Quarterfinalists stumbled in midweek PSL games, but they could have held back for Telkom tournament.
The Amakhosi have made a great start to the season but a resurgent Pirates are after the MTN8 booty.
Orlando Pirates have ended their football season with at least one trophy after beating Wits in the Nedbank Cup final in Durban.
After a draining but barren season, Orlando Pirates hope to lift a trophy in the last PSL match.
Following a draw against Platinum Stars, Vladimir Vermezovic hopes the Bucs will finish the Premiership season in the top half of the standings.
Kaizer Chiefs coach Stuart Baxter celebrated his first ever Premiership win over Orlando Pirates in a famous 1-0 victory during the Soweto Derby.
The Premier Soccer League lead could be hauled in if Kaizer Chiefs lose to Orlando Pirates in the Soweto derby.
Communications agency Portland has looked at tweets from Africa to determine what languages are used the most and what issues drive the conversation.
Following the resignation of Roger de Sa, the imminent arrival of the new coach Vladimir Vermezovic has saddened interim boss Eric Tinkler.