A second half penalty, and a runaway goal from substitute Wakaso Mubarak helped favourites Ghana beat a resilient Cape Verde Islands side 2-0.
South Africa will receive all the home support at thequarter-final against Mali while the international spotlight will be on tiny Cape Verde Islands.
After drawing with South and Morocco, Cape Verde are hoping to gain a win over Angola to qualify for the Afcon quarterfinals.
Bafana Bafana kicked off the opening match against Cape Verde, but left millions of South Africans disappointed with the match drawn at 0-0.
Hosts South Africa and Cape Verde Islands drew 0-0 at Soccer City stadium in a lacklustre opening match of the 2013 Africa Cup of Nations tournament.
The luck of the draw has pitted African Cup of Nations hosts South Africa against debutants Cape Verde in the tournament's opening game next year.
The Cape Verde Islands have secured a place at Afcon for the first time and former champs Ethiopia are back in the big time after a 30-year absence.
Cape Verde has decided to re-name its Praia International Airport after South African freedom icon and former president Nelson Mandela.
Stephen Gray visits Cape Verde, one of the world's most arid desert islands, and discovers hope and an extraordinary lyricism amid the poverty.
Cape Verde's deportees say they return home only to find plentiful drugs, unemployment and discrimination.