Facing an extremely hostile attack, New Zealand were in deep trouble trailing South Africa by 478 at stumps on day two in Port Elizabeth.
Proteas' Rory Kleinveldt has failed a doping test by the South African Institute for Drug-Free Sport, testing positive for a "specified substance".
A five-wicket haul for Rory Kleinveldt helped the Cobras dismiss the Knights for 218 on day one of their SuperSport Series match against the Cobras.
Rusty Theron of the Warriors is the only uncapped player included in the final Proteas' Pro20 squad for the ICC World Twenty20.
Herschelle Gibbs, who has been going through a lean period in recent weeks, bounced back on Wednesday, making an unbeaten 74 to take the Cape Cobras to a massive seven-wicket victory over the Lions in their MTN Domestic Championship match at the Wanderers.
On a day on which 18 wickets fell, Friedel de Wet claimed his tenth five wicket haul with figures of six for 50 to give South Africa A a commanding lead of 271 at the end of the second day of their four-day match against New Zealand at Sedgars Park on Friday.
The Titans had a slender first-innings lead of 10 runs with four wickets in hand when bad light stopped play on the third day of their SuperSport Series match against the Cape Cobras at Willowmoore Park in Benoni on Saturday. In Johannesburg, the Lions were playing the Warriors.
The Warriors' Lonwabo Tsotsobe finished with career-best figures of seven wickets for 39 runs from 21 overs in their SuperSport Series match against the Lions at the Wanderers in Johannesburg on Friday. In Benoni, the Cobras were playing the Titans and in Durban it was the Eagles and the Dolphins.