Australia's Ryan Harris took the last two wickets as South Africa came within five overs of saving the third Test - skipper Graeme Smith's final game.
Graeme Smith's departure from international cricket will push the Proteas into a new period - lacking experience and, potentially, a leader.
After claims that the Proteas tampered with the ball in the second Test, Australia's David Warner has gone to lunch with an unbeatn half-century.
Graeme Smith had an ominous warning for the Australians after the Proteas crushed the visitors by 231 runs in Port Elizabeth on Sunday.
The Proteas will face India at Kingsmead in their final Test, fighting not only a strong Test team but a four-defeat jinx at the Durban pictch.
The Proteas defeated Pakistan by four wickets in the final match of the series in Centurion on Saturday.
South Africa achieved a bitter-sweet 28-8 Rugby Championship victory over Australia on Saturday at Newlands in Cape Town.
South Africa faced a defeat before two late second half penalties from Morne Steyn gave them a 22-17 win over an improved Argentina on Saturday.
Cheetahs prop Trevor Nyakane has been dropped for repeated breaches of team protocol as coach Heyneke Meyer announced his squad to Argentina.
The Cheetahs' hopes of reaching the Super Rugby play-offs for the first time suffered a blow when they were defeated 28-3 by the Stormers on Saturday.