The N1 highway southbound near the John Vorster Avenue offramp in Centurion was re-opened to traffic on Wednesday after a toxic spill, Tshwane metro police said.
Spokesperson Louise Britz said the highway and offramps were opened to traffic.
Britz said drivers had listened to radio reports advising the use of alternative routes and so there was no traffic back-up.
The road was closed when about 10 000 litres of sulphuric acid spilled onto the offramp when a truck transporting it overturned on Tuesday afternoon.
Emergency services spokesperson Johan Pieterse said the driver of the truck had lost control of the vehicle.
He said many people had reported damage to the paintwork of their cars and to their tyres after driving over the acid.
Pieterse said a special clean-up team were contracted to contain the spillage and had taken it to a safe place for disposal. — Sapa