Forever young no longer just a dream

In a study in mice, American researchers found that two licensed drugs were effective at eliminating senescent cells from fat tissue and bone marrow.

In a study in mice, American researchers found that two licensed drugs were effective at eliminating senescent cells from fat tissue and bone marrow.

It is generally accepted as one of life’s unfortunate but inevitable facts: we might be able to disguise the wrinkles for a time, but ageing will get us all in the end. Except scientists are now questioning whether it has to be so, or whether age is simply another disease that might one day be conquered.

American researchers have suggested that the elixir of eternal youth – or at least extended middle age – may be on the horizon.

After discovering two drugs that appeared to invigorate elderly mice, the scientists, from the Scripps Research Institute in Florida, have coined the term “senolytics” for a new class of drugs designed to delay ageing.

Their research focuses on senescent cells – cells we acquire throughout life that shut down, stop dividing and sit there making few useful contributions to our lives.

“Senescence used to be thought of as an inert state,” Sian Henson, a specialist in ageing at University College London, said. “But we now know they make a whole load of things that are bad for you.
They’re definitely trouble.”

The older we get, the more of these cells we have. As they sit in our tissues pumping out harmful inflammatory molecules, they trigger senescence in neighbouring cells, accelerating the ageing process. The logical solution, the Scripps team reasoned, would be to get rid of senescent cells.

In a study in mice, they found that two licensed drugs were effective at eliminating these cells from fat tissue and bone marrow.

When the mice were given the cancer drug dasatinib (targeting fat) and the antihistamine quercetin (bone marrow), they had improved cardiovascular function, better stamina, reduced osteoporosis and frailty, and extended healthy lifespan.

Evident benefits
The benefits were evident within five days of treatment and lasted for seven months, according to a paper in the journal Aging Cell.

“We view this study as a big first step towards developing treatments that can be given safely to patients to extend ‘healthspan’ or to treat age-related diseases and disorders,” said Professor Paul Robbins, who led the research.

Henson agreed that the approach made sense, but said it would be some time before senolytics were available on prescription. “Overall, what they’re doing is sensible,” she said. “[But] would I want to take what they gave to the mice? I don’t think so.”

A central drawback, she said, was that, unless you replaced senescent cells with healthy cells, “you would actually shrink a bit”. After a few rounds of treatment, the process would presumably become unsustainable.

A promising alternative to drugs, Henson said, would be to harness the body’s own immune system to sweep out senescent cells more gradually, giving the body time to replace them.

Preliminary work suggests that T-cells, which normally target disease, can be genetically engineered to target senescent cells in a wide range of tissues. In future, an infusion of genetically modified blood every few years might be able to keep you going indefinitely (assuming some major advances in treating cancer, Alzheimer’s and heart disease).

At which point, the question might not be “how long have I got?”  but rather “how long do I want to stick around?” – © Guardian News & Media 2015

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