An American and two British researchers won this year’s Nobel Prize in medicine or physiology for discoveries concerning how genes regulate organ development and a process of cell suicide.
South African-born Sydney Brenner (75) and John Sulston (60) of Britain and American Robert Horvitz (55) shared the prize, worth 10-million kronor ($1-million). The laureates have identified key genes regulating organ development and programmed cell death. The discoveries have shed new light on the development of many diseases, including Aids, neurodegenerative diseases and strokes.
The announcement opened a week of Nobel Prizes that culminates on Friday with the prestigious peace prize, the only one revealed in Oslo, Norway.
Brenner, a researcher at the Molecular Sciences Institute in Berkeley, California, broke new ground demonstrating that different mutations could be linked to specific genes and to specific effects on organ development, the basis for this year’s prize. Working with worms, Sulston of Cambridge identified the first mutation of a gene participating in the cell death process. Horvitz of the Massachusetts Institute of Technology showed how the genes interact with each other in the cell death process and that corresponding genes exist in humans.
The physics award will be announced on Tuesday and the chemistry and economics awards on Wednesday in the Swedish capital. As in years past, the date for the literature prize has not been set. But it always falls on a Thursday, usually the same week as the other awards.
The award committees make their decisions in deep secrecy and candidates are not publicly revealed for 50 years. Alfred Nobel, the Swedish industrialist and inventor of dynamite, left only vague guidelines in his will establishing the prizes, first awarded in 1901. For the prize on Monday, he simply stated the winner ”shall have made the most important discovery within the domain of physiology or medicine.”
The 18 lifetime members of the Swedish Academy who choose the literature laureate make their final decision at one of their weekly meetings, only setting the date early in the same week to keep the world guessing. Kaj Schueler, a literary editor at Swedish daily newspaper Svenska Dagbladet, predicted the academy’s choice would be a surprise since last year’s award went to perennial favorite VS Naipaul.
”I also think it’s time for them to pick a poet,” Schueler said, declining to single out any names. ”The last poet they had was the Polish writer Wislawa Szymborska in 1996. since they they’ve had playwrights and prose writers.”
The only public hints are for the peace prize. The five-member awards committee never reveals the candidates, but sometimes those making the nominations announce their choices. With the world still reeling from last year’s September 11 terrorist attacks and concerned about US plans for a war in Iraq, no clear favorites have emerged.
Among the nominees were Afghan President Hamid Karzai, who has sought to unify his country after the hard-line Taliban was ousted by US-led airstrikes, former New York City Mayor Rudolph Giuliani, the Salvation Army and the US Peace Corps.
President Bush and British Prime Minister Tony Blair were
nominated for leading the war against terrorism but were seen as unlikely winners in wake of their efforts to convince the world of the need to overthrow Saddam Hussein.
The Nobel Assembly at the world-renowned Karolinska Institute, which selects the medicine prize winner, invites nominations from previous recipients, professors of medicine and other professionals worldwide before whittling down its choices in the fall.
Last year’s winners were Leland Hartwell of the United States and Timothy Hunt and Paul Nurse from Britain for discovering key regulators of the process that lets cells divide, which is expected to lead to new cancer treatments.
The awards always are presented on December 10, the anniversary of Nobel’s death in 1896. – Sapa-AP