Coenie Oosthuizen will also earn his first cap, though he plays off the bench.
Zane Kirchner won the battle for selection at fullback ahead of Patrick Lambie, who was named on the bench.
Frans Steyn, who was based in France will join the Sharks next month, plays at inside centre.
It was also confirmed that Bismarck du Plessis will be the vice-captain to Jean de Villiers in South Africa’s first international since tlast year’s World Cup.
Springbok team: Zane Kirchner, JP Pietersen, Jean de Villiers (captain), Frans Steyn, Bryan Habana, Morne Steyn, Francois Hougaard, Pierre Spies, Willem Alberts, Marcell Coetzee, Juandre Kruger, Eben Etzebeth, Jannie du Plessis, Bismarck du Plessis, Beast Mtawarira. Replacements: Adriaan Strauss, Coenie Oosthuizen, Flip van der Merwe, Keegan Daniel, Ruan Pienaar, Patrick Lambie, Wynand Olivier. – Sapa