/ 23 December 2005

Alleged cloned dog cavorts in snow

While South Korea’s most famous scientist was resigning on Friday in scandal after his university said key research was faked, one of his greatest purported breakthroughs was cavorting in the snow.

Snuppy, an Afghan hound that researcher Hwang Woo-suk said he cloned, was shown in photographs by South Korean media being led by a handler on a leash through the grounds of Seoul National University’s animal hospital, where the dog is now kept.

”Lonely Snuppy after Professor Hwang leaves,” Yonhap news agency wrote in one photo caption.

”Snuppy’s well,” an official at the animal hospital said, refusing to give her name or more details.

Hwang revealed Snuppy — named for Seoul National University puppy — in August, claiming to have created the world’s first cloned dog. But like his other breakthroughs in stem-cell science, that assertion is now being questioned.

A university panel that had been investigating a May paper in the journal Science on Hwang’s stem-cell research said on Friday that Hwang had fabricated those results, and that it is also now investigating the claims of the cloned dog.

Blood samples related to Snuppy have been sent for DNA testing, the panel said on Friday.

Although other animals have previously been cloned successfully, applying the technique to a dog had been seen as significant because of the difficulties in working with canine eggs.

Hwang had said his workers used DNA of skin cells taken from the ear of a three-year-old male Afghan hound to replace the nucleus of unfertilised eggs. Nearly 1 100 embryos were created and transferred to 123 surrogates, but only three pregnancies resulted, according to Hwang’s paper published in the journal Nature.

Of those, there was one miscarried foetus and two puppies delivered by Caesarean section after 60 days. One died of pneumonia 22 days after birth — leaving Snuppy as the sole survivor.

Hwang posed smiling with the dog in his arms when announcing his alleged achievement in August. The dog garnered worldwide fame, with United States-based Time magazine later naming it the ”most amazing invention” of 2005.

American scientist Gerald Schatten, who collaborated on the project, at the time called Snuppy ”a frisky, healthy, normal, rambunctious puppy”.

Now some are wondering if Snuppy, now eight months old, was just that.

Nature said this week it is reviewing the paper in light of questions raised about Hwang’s other research.

A top international stem-cell researcher also questioned on Friday if the dog had really been cloned.

”I think a lot of the community were very impressed with the cloning of a dog — and it was a delightful dog — but I actually don’t think it is a cloned dog now,” said Professor Alan Trounson, of Australia’s Monash University. — Sapa-AP