China scientist claims world’s first gene-edited babies

A scientist in China claims to have created the world’s first genetically-edited babies, in a potentially ground-breaking and controversial medical first.

Chinese university professor He Jiankui posted a video on YouTube saying that the twin girls, born a few weeks ago, had had their DNA altered to prevent them from contracting HIV.

The professor, who was educated at Stanford in the US and works from a lab in the southern Chinese city of Shenzhen, said their DNA was modified using CRISPR, a technique which allows scientists to remove and replace a strand with pinpoint precision.

The development emerged on Sunday in an article published by industry journal the MIT Technology Review, which referenced medical documents posted online by He’s research team at the Southern University of Science and Technology to recruit couples for the experiments.

He’s video then went online, prompting a heated debate among the scientific community, including from experts who cast doubt over the claimed breakthrough, and others who decried it as a modern form of eugenics.

He said the babies, known as “Lulu” and “Nana” although they are not their real names, were born through regular IVF but using an egg which was specially modified before being inserted into the womb.

“Right after sending her husband’s sperm into her egg, an embryologist also sent in CRISPR/Cas9 protein and instructions to perform a gene surgery intended to protect the girls from future HIV infection,” he said.

The claims come ahead of a conference of world experts in Hong Kong on Tuesday, where He is expected to reveal more details.

But there is as yet no independent verification of his claims, which have not been published in a peer-reviewed journal — an omission that the scientist’s critics have seized on.

‘Highly problematic’

The MIT Technology Review warns that “the technology is ethically charged because changes to an embryo would be inherited by future generations and could eventually affect the entire gene pool.”

Other scientists have also sounded caution.

Nicholas Evans, assistant professor of philosophy at the University of Massachusetts Lowell, said on Twitter that the claims were “wild”.

“On a basic level, announcing the test through a YouTube video is a highly problematic form of scientific practice, as it steps aside the vetting processes on which a lot of scientific advance relies, such as peer review,” he told AFP.

“We’ve been talking about genetic engineering of embryos for a while… what is a bit more revolutionary is that these children were allegedly engineered to provide resistance to a disease. That’s a new step forward, and where a lot of peril is.”

The issue of editing human DNA is extremely controversial, and only allowed in the US in laboratory research — although US scientists said last year that they had successfully edited the genetic code of piglets to remove dormant viral infections.

But this is not the first time Chinese researchers have experimented with human embryo technology, and last September scientists at Sun Yat-sen University in China used an adapted version of gene-editing to correct a disease-causing mutation in human embryos.

Sam Sternberg, assistant professor in biochemistry and molecular biophysics at Columbia University, questioned the whole premise of He’s research, noting that it was not aimed at fixing a life-threatening condition — like a genetic disease for example.

READ MORE: Scientists caution against dangers of genetic modification

“Missing from the video is the fact that edits were made to embryos that do NOT have HIV. Changes risk/benefit big-time,” he tweeted.

“This breaking news story sure is an absolute bombshell for the #GeneEditSummit in Hong Kong this week. No doubt countless speakers are scrambling to update slides as we speak.”

He Jiankui did not immediately respond to a request for comment from AFP.

Neither was there any response from queries to the organisers of the Hong Kong conference, and it is not clear whether they were aware of He’s work.

In a pre-recorded video on the conference’s website, biologist and chair of the international summit David Baltimore said: “We have never done anything that will change the genes of the human race, and we have never done anything that will have effects that will go on through the generations.”

© Agence France-Presse


Senior SANDF colonel involved in an alleged business scam

A senior soldier who is part of South Africa’s peacekeeping missions is accused by her colleagues of swindling them out of of hundreds of thousands of rands in a nonexistent business deal

AU pushes the frontiers of transitional justice

Now these important policy developments must be implemented

Mass store and job cuts at Massmart

Changed market conditions and an appalling economy has hit low end cash-and-carry outlets

Courts to guide land expropriation

Two bits of law need to be approved before a court can decide if land owners will be compensated

Press Releases

New-style star accretion bursts dazzle astronomers

Associate Professor James O Chibueze and Dr SP van den Heever are part of an international team of astronomers studying the G358-MM1 high-mass protostar.

2020 risk outlook: Use GRC to build resilience

GRC activities can be used profitably to develop an integrated risk picture and response, says ContinuitySA.

MTN voted best mobile network

An independent report found MTN to be the best mobile network in SA in the fourth quarter of 2019.

Is your tertiary institution is accredited?

Rosebank College is an educational brand of The Independent Institute of Education, which is registered with the Department of Higher Education and Training.

Is your tertiary institution accredited?

Rosebank College is an educational brand of The Independent Institute of Education, which is registered with the Department of Higher Education and Training.

VUT chancellor, Dr Xolani Mkhwanazi, dies

The university conferred the degree of Doctor of Science Honoris Causa on Dr Xolani Mkhwanazi for his outstanding leadership contributions to maths and science education development.

Innovate4AMR now in second year

SA's Team pill-Alert aims to tackle antimicrobial resistance by implementing their strategic intervention that ensures patients comply with treatment.

Medical students present solution in Geneva

Kapil Narain and Mohamed Hoosen Suleman were selected to present their strategic intervention to tackle antimicrobial resistance to an international panel of experts.